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Is it Safe to Combine Phentermine with Other Diet Pills?

safe to combine Phentermine

If you’ve talked to your doctor about having a lot of trouble losing the weight that you need to shed in order to get healthier, he or she may have offered you a prescription for the popular diet pill known as Phentermine. But is taking Phentermine enough, or should you also consider taking another diet pill at the same time? Is it really safe to combine Phentermine with other diet pills? Keep reading to learn more about this important topic so you can make the best and safest choice for your weight and your overall health.

What Some Doctors Combine Phentermine With

There are some instances in which a doctor may prescribe more than one weight loss drug. Phentermine combinations are designed to maximize the potential benefits of Phentermine, thereby helping you lose weight with greater ease and speed. For example, a doctor may prescribe Phentermine along with a low-dose prescription of an anti-depressant like Zoloft or Prozac. This combination may be referred to as Phen-Pro. But rather than treating depression, the idea here is to assist Phentermine so that it could help you shed pounds more quickly.

Qsymia is actually a drug that combines Topiramate, which is an anti-convulsant medication, with Phentermine. That’s because Topiramate’s side effects include weight loss. Even though Qsymia is available, though, some doctors may actually write up two prescriptions for Topiramate and Phentermine. And Phentermine might even be combined with other weight loss options in new and upcoming drugs.

Combinations No Longer Available

Our understanding of Adipex diet pills is continually evolving.  Just because a combination has previously been approved, it doesn’t mean that it will automatically be acceptable forever.  Doctors, the FDA and other organizations are continually monitoring the safety of ways to combine Phentermine with other medications.  There are certain examples of combinations that have previously received the nod from the FDA but that have since been withdrawn.  The two most well known are the classic Fenfluramine (of Fen-Phen fame) example, and the recently approved and withdrawn Belviq pill.


Fenfluramine was the “fen” portion of the Fen-Phen medication that had been approved by the FDA and was used as an obesity treatment for many years. Researchers had found that when you combine Phentermine (the Phen half of that drug) and Fenfluramine, there were benefits that could help obesity patients. Health issues had been reported for years, but the drug continued to be prescribed and used. In the early 1990s, researchers from France reported a link between the use of Fenfluramine and primary pulmonary hypertension and dyspnea within a small patient sample.

By 1997, Fenfluramine was withdrawn from the US market following heart valve disease reports and ongoing pulmonary hypertension reports, including those associated with cardiac fibrosis.  This made it illegal to continue prescribing or selling a drug that would combine Phentermine with Fenfluramine.


Belviq (Lorcaserin) was a drug sold as an alternative to Adipex or a medication that would combine Phentermine with another medication as is the case with Qsymia – a drug approved by the FDA within a short time of Belviq’s approval.

Belviq was first approved in 2012 as an obesity treatment. This was an important approval as it was the first obesity drug to receive FDA approval in many years and that didn’t combine Phentermine with something else.

Unfortunately, in February 2020, the FDA asked the company behind this drug to voluntarily withdraw it, due to an ongoing indication that use of this medication increases the risk of certain cancers.  Eisai Inc did voluntarily withdraw this drug and is continuing to conduct research and data analyses to better understand this potential risk and if it is accurate.

This greatly placed the focus back on drugs that combine Phentermine with other medications after the obesity industry had been starting to look to a larger number of other substances.

Combining Phentermine is Only Safe If Your Doctor Prescribes It

The combinations listed above are just a few of the options that your doctor has when helping you find the right diet pills for your needs. But it’s important to note that you should take Phentermine with another diet pill only if your doctor has prescribed the combination, discussed the safety and side effects with you, and explained why the combination is appropriate for you. This is important regardless of whether the combination includes other prescription medications or even non-prescription supplements developed with weight loss support in mind.

Something Else to Consider

Although some doctors will combine Phentermine with other drugs, some experts aren’t keen on the idea of giving patients Phentermine with other weight loss pills, as the potential for side effects may be too high. This is why talking to your doctor about the possible benefits and dangers of Phentermine combinations is important.

Ultimately, it’s up to your doctor to decide what diet pill is best for you and if a combination of diet pills would be right for you. Just be sure to follow your doctor’s instructions closely in terms of dosage and how long you should take the diet pills.

Combine Phentermine with a Healthy Diet and Regular Exercise

Though there may be a limited number of options available to combine Phentermine with other substances in order to safely treat obesity, there are certain combinations that remain effective with this drug quite consistently.  Those are in the form of healthy calorie-controlled diet and regular exercise.  Those will always be the lead recommendations for obesity patients treating their conditions with this prescription drug.


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